A brilliant evil scientist named "The Reverend" has created a powerful theocracy based on the idea of a rapidly approaching apocalypse. He uses his expertise to create four powerful "Horsemen of the Apocalypse", War, Plague, Beast and Death, in order to ensure this comes to pass. His former colleague, Trey Kincaid (voiced by Bruce Willis), is the only man with the know-how to stop the Reverend, but is locked up in jail and must escape in order to save the world.