Westward II: Heroes of the Frontier

Set after the previous game, the town of Hope River is suddenly destroyed. Fleeing residents bring tales of Doc Vostrikov, the "Mad Russian", who once again tries to stop further expansion with the help of his cronies—the Copperhead Gang. Three pioneers help these refugees find new homes and expand into new communities by establishing new settlements. Source: Wikipedia, "Westward (series)", available under the CC-BY-SA License.