The year is 1806, and the small town of Insel in the kingdom of Berkgard is being terrorized by vampires. The ISLA -- the International Spiritually Liberators Association -- is an organization dedicated to eradicating the threat of vampires wherever they may be found. With Insel paralyzed by these nefarious creatures, the ISLA has sent three of their most capable agents in to protect the people and kill the vampires. Vampire Panic is a third-person action game with minor adventure and stealth elements. Controlling one of the three ISLA agents, the player must eliminate the vampire infestation in Insel and escort as many residents as possible to safety outside the town. Vampires can attack by biting either the player or friendly villagers, causing them to start turning; if the transformation completes before the affliction can be healed, villagers will turn into enemies and can no longer be saved, while the player turning results in an immediate game over. The game's story will change depending on which and how many villagers the player is able to rescue.