Two Rooms is a co-operative card game for two players in which a group of humans has entered the House of Mist and must escape the vampires within. The game takes place in the two halves of the game box, one depicting a red door, and the other a green door. The game centers around a deck of 15 cards. On your turn, draw a card from the deck and place it into one of the two rooms. When you "open" the room to add the card, you look at the cards already present and resolve their effects in ascending numerical order. Some effects will remove cards to the casualty area, others will cause cards to switch rooms, and so on. While this is happening, the other player must keep their eyes closed. The game comes with four difficulty levels, and the players win if the Cloaked Vampire is placed in the casualty area and the players know the location of one of the human cards, Nina. The players lose in a number of ways, such as Nina entering the casualty area or the deck running out of cards.