The Last Man (2011)

From the introduction: In this game you play the role of the unique survivor of humankind after an outbreak, an apocalypse or something similar. Other humanoids are roaming outside, but they’re no more human, something has changed them so much that they haunt you as a prey. You have to survive. Alone. ... The first and most important rule of this game is: Trust No One. User summary: This solitaire game is best played in a house with other (non-playing) occupants. The game features a unique mechanism of using these other occupants as a sort of random event generator.