The object is to "infect" as many players as you can using the cards in your hand and those available from a 5-card draw pool before the draw deck in gone. Each STD has a point value. At the end of the hand, the lowest score wins. There are 3 ways to "infect" another player: 1- creating a 3 of a kind and passing it to a player 2- after each turn, give 1 of the STDs from your hand to the player on your right 3- using a special event card that allows you to give half of the STDs you've been "infected" with to another player. Beware of the HIV card... if you end up with it at the end of the game your points double.