Bananagrams is a Scrabble-like game without the board that's much like Pick Two!, but without the letter values. In the regular game, using a selection of 144 plastic letter tiles, each player works independently to create their own "crossword". When a player has incorporated all of their letters in their crossword, all players take a new tile from the pool. When all the tiles are gone, the first player to use up all the tiles in their hand wins. By contrast, My First Bananagrams has 80 lower-case letters and 13 dual-letter combo tiles that players use in multiple activities and minigames.