Missionary Blues is a card game similar to Crazy Eights. The cards all have a Mormon Missionary Theme. Players must match the top card of the discard pile with either the same suit or a matching number. Whenever a player changes suit, either by number or one of the wild cards, s/he collects a Letter from the Mission President Card, which has a point value. At the end of the game, the player with the highest point total wins. Special cards that cause opponents to Draw Four, Reverse play order, and discard all cards of one color are included and have artwork relevant to Mormon missionaries such as Zone Leaders, APs, and a "Little Devil" - which can bounce the power of a negative card back to the player.