In MindMazeMix, as in other MindMaze sets, players take turns asking questions to try to solve mysteries. This particular set features eleven challenges from each of the first four MindMaze sets: Wahre Geschichten, Kriminalfälle, Rabenschwarze Geschichten, and Geld, Ruhm und Macht. In general, a referee tells a strange story, then the players must determine why and how the story happened by asking "Yes" or "No" questions, with "Not Important" also being a plausible answer. Players take turns asking questions, with a point being subtracted for each question. Players are awarded points for asking certain key questions that eliminate faux versions of the story. The list of useful key questions is attached to every riddle. This sort of gaming procedure effectively encourages players to develop careful analytical questions and eliminates random questions.