La Última Enfermera is a game about the "crazy" work that nurses usually have to do. At this game each player represents a nurse at a job center, and one day they are called to start a work at the hospital on a random medical field, where they have to fulfill tasks. At the beginning of the game each player is given a secret Identity Card (each of them related to a different field where you can work at, and each of them of different colour). A deck is then formed with all the other cards (Task, Situation, Character and Item cards) shuffled. Each turn the player on turn has to draw a new card from the deck, add it to his hand (unless it's a Situation card, in which case it's resolved inmediately. Usually it's an event which changes something on the game, like shuffling all Identity cards of the players and re-dealing at random), and finally has to play or discard one card from it's hand. Task cards can only be played (face down near the Identity card of that player) if it's a task of that type of work (it's of the same colour). If the card doesn't match your Identity card colour it has to be discarded. Characters and Items are played to make it's special action. The first player to have 5 Task cards of it's colour wins the game.