Kamigami Battles: Rise of the Old Ones is a standalone game that's compatible with other Kamigami Battles titles. The gameplay remains mostly the same as you play the role of a great God or a team of Gods, defending your reign from rival Gods by using the warriors and disciples loyal to you. In this version of the game, each player chooses to be a member of the pantheon of Old Gods from H.P. Lovecraft's mythos, such as Cthulhu or Hastur. When playing with 2 to 6 players, you win by reducing all of the other Gods to 0 energy or by reaching 25 energy. When in a Team Match, you play with 4 or 6 players teamed up in pairs of two. You will have one Main God and a Support God. A team wins together if they can eliminate the opposing team's Main God. Rise of the Old Ones introduces a new game mechanism to this world known as Artifacts.