Gut Check is a game for 2-4 players where each player attempts to develop a healthy microbiome while interfering with the microbiomes of their opponents. Give your friends the plague, botulism and more! Go to work sick to get rid of a pathogen, take some probiotics, or have some lasagna (if you can digest it). The game takes 30-60 minutes to play, depending on experience and number of players. Gut Check draws on elements from a number of games including Pandemic, Magic: The Gathering, and Dominion. While the game plays equally well with 2, 3, or 4 players the strategy changes in each case. Optimal play revolves around hand management, card cycling, striking a balance between building your own microbiome or playing cards to interfere with opponents, and timing various events.