Each player has tokens representing 5 different organs (heart, lungs, brain, kidney, and liver). In your turn, you must play a card in order to damage another player organ, cure yourself, lower the defense of other players (easier to damage organs), raise your defense, exchange an organ with another player or damage an organ of all the other players. When a player has all the five organs damaged, he can't win, but still can annoy the others. A player is declared the winner when he is the last alive.