In Destroy BCN, players take on the roll of massive mutant monsters that lay waste to the fair city of Barcelona, demolishing buildings in their wake while army detachments (and other monsters) try to destroy them in turn. Each player controls one of these monsters. On their turn, the player moves the monster (destroying buildings, attacking armies or attacking other monsters), then they can move two armies to attack other monsters. While destroying or attacking, the player gets victory points — and when a player is attacked, they lose victory points. If only three armies are on the board, or no buildings are present, or a monster is eliminated, the game ends and the player or team with the most victory points wins.