From the introduction: This supplement is written by medical students with a love for tabletop roleplaying games. Inspired by the wide array of diseases, and the medieval myths that once surrounded them, we embarked on a mission; to enrich other worlds with fantastic diseases. Herein are presented a plethora of diseases, varying from magical to microbiological causes. We feel that every disease is something to be feared. Deep in each civilization’s roots, there are myths, remedies and folklore, all revolving around the ailments that affect its people. When each Dungeon Master wants to expand on the details of the societies that unfold before their very eyes, tools that spice up the process become a vital weapon. This supplement will hopefully become one of them, as DMs become inspired by the grim, epic or mundane conditions of the human body and mind.