In Amoeba, players draw and place tiles in order to build the biggest amoebas, then they claim those amoebas by placing their nuclei markers on them. Players can also place tiles on top of completed amoebas to split them, reducing an opponent's score. There are twelve unique tiles that will require pattern recognition and strategic thinking to grow the largest amoeba. The game ends when all tiles are played, and the player with the biggest amoeba wins.